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Belotecan hydrochloride
CAS No. 213819-48-8
Belotecan hydrochloride( CKD-602 )
Catalog No. M20796 CAS No. 213819-48-8
Belotecan hydrochloride is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 58 | In Stock |
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| 10MG | 87 | In Stock |
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| 25MG | 140 | In Stock |
|
| 50MG | 200 | In Stock |
|
| 100MG | 281 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBelotecan hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionBelotecan hydrochloride is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity.
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DescriptionBelotecan hydrochloride is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity.(In Vitro):Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.(In Vivo):Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.
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In VitroBelotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.
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In VivoBelotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.
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SynonymsCKD-602
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PathwayCell Cycle/DNA Damage
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TargetTopoisomerase
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RecptorTopo I
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Research AreaCancer
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IndicationNon-small cell lung Cancer; Solid tumours
Chemical Information
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CAS Number213819-48-8
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Formula Weight469.96
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Molecular FormulaC25H28ClN3O4
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Purity>98% (HPLC)
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SolubilityDMSO:50 mg/mL (106.39 mM)
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SMILESCCC1(O)C(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1ccccc1c2CCNC(C)C.Cl
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Chemical Name(4S)-4-Ethyl-4-hydroxy-11-[2-[(1-methylethyl)amino]-ethyl]-1H-pyrano[3'4':67]indolizino[12-b]quinoline-314(4H12H)dione hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kim Y K Koo N Y Yun P Y . Anticancer effects of CKD-602 (Camtobell (R)) via G2/M phase arrest in oral squamous cell carcinoma cell lines[J]. Oncology letters 2015 9(1):136-142.
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